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FOCUS

Volume 8, Issue 4

Psychopharmacology: Treatment-Resistant Disorders

October 2010

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FROM THE GUEST EDITOR

October 2010

From the Guest Editor

Charles B. Nemeroff, M.D., Ph.D.

Page:473
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc473

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CLINICAL SYNTHESIS

October 2010

Advances in the Management of Treatment- Resistant Schizophrenia

Jacob S. Ballon, M.D., and
Jeffrey A. Lieberman, M.D.

Pages:475–487
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc475

Abstract
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Schizophrenia is a serious mental illness responsible for tremendous morbidity and decreases in quality of life and productivity. It is the eighth leading cause of disability-associated life years lost () and accounts for nearly 1.1% of overall losses ...

October 2010

Advances in the Management of Treatment-Resistant Depression

Paul E. Holtzheimer, M.D.

Pages:488–500
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc488

Abstract
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Treatment-resistant depression (TRD) is a prevalent, disabling, and costly condition affecting 1%–4% of the U.S. population. Current approaches to managing TRD include medication augmentation (with lithium, thyroid hormone, buspirone, atypical ...

October 2010

Advances in the Management of Treatment-Resistant Anxiety Disorders

Nicole M. Lanouette, M.D., and
Murray B. Stein, M.D., M.P.H.

Pages:501–524
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc501

Abstract
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Anxiety disorders are among the most common and disabling mental illnesses. While effective treatments exist, many patients—possibly even 50–60%—remain symptomatic despite first-line treatments. With the exception of obsessive compulsive disorder (OCD), ...

October 2010

New Vistas in the Management of Treatment-Refractory Psychiatric Disorders: Genomics and Personalized Medicine

Amanda J. Myers, Ph.D., and
Charles B. Nemeroff, M.D., Ph.D.

Pages:525–535
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc525

Abstract
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To date, most therapies of treatment-refractory psychiatric disorders involve modifications of existing pharmacological treatments and/or cognitive therapies. However, many of these strategies are unable to bring these disorders into remission; therefore, ...

October 2010

Patient Management Exercise: Psychopharmacology: Treatment-Resistant Disorders

Ian A. Cook, M.D.

Pages:536–539
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc536

Abstract
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This exercise is designed to test your comprehension of material presented in this issue of FOCUS as well as your ability to evaluate, diagnose, and manage clinical problems. Answer the questions below, to the best of your ability, on the information ...

October 2010

Ethics Commentary Ethics in Psychopharmacology Research

Laura Weiss Roberts, M.D., M.A., and
Thomas Heinrich, M.D.

Pages:540–546
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc540

First Page
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October 2010

Ask the Expert: Sexual Dysfunction Medication, Hormones, and Nutrition

Barbara Bartlik, M.D.

Pages:547–549
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc547

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INFLUENTIAL PUBLICATIONS

October 2010

Bibliography: for Psychopharmacology: Treatment-Resistant Disorders

Pages:550–553
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc550

Abstract
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This section contains a compilation of recent publications that have shaped the thinking in the field as well as classic works that remain important to the subject reviewed in this issue. This bibliography has been compiled by experts in the field and ...

October 2010

Abstracts: for Psychopharmacology Treatment-Resistant Disorders

Pages:554–560
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc554

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October 2010

Does Switching to a New Antipsychotic Improve Outcomes? Data from the CATIE Trial

Robert A Rosenheck,
Sonia Davis,
Nancy Covell,
Susan Essock,
Marvin Swart,
Scott Stroup,
Joseph McEvoy, and
Jeffrey Lieberman

Pages:561–569
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc561

Abstract
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Purpose:Previous analysis of data from CATIE showed that patients randomly assigned to switch to a new medication were more likely to discontinue study drug than those who stayed on the medication they had been taking prior to randomization. This study ...

October 2010

Atypical Antipsychotic Augmentation in Major Depressive Disorder: A Meta-Analysis of Placebo-Controlled Randomized Trials

J. Craig Nelson, M.D., and
George I. Papakostas, M.D.

Pages:570–582
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc570

Abstract
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Objective:The authors sought to determine by meta-analysis the efficacy and tolerability of adjunctive atypical antipsychotic agents in major depressive disorder. Method:Searches were conducted of MEDLINE/PubMed (1966 to January 2009), the Cochrane ...

October 2010

Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

Andres M. Lozano,
Helen S. Mayberg,
Peter Giacobbe,
Clement Hamani,
R. Cameron Craddock, and
Sydney H. Kennedy

Pages:583–591
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc583

Abstract
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Background:A preliminary report in six patients suggested that deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant depression (TRD). We now report the results of these and an additional 14 ...

October 2010

Comprehensive Analysis of Remission (COMPARE) with Venlafaxine versus SSRIs

Charles B. Nemeroff,
Richard Entsuah,
Isma Benattia,
Mark Demitrack,
Diane M. Sloan, and
Michael E. Thase

Pages:592–604
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc592

Abstract
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Background:To compare venlafaxine and selective serotonin reuptake inhibitors (SSRIs; fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram) in the treatment of depression. Methods and Materials:Meta-analysis of 34 randomized, double-blind ...

October 2010

Efficacy of Second Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence

J. Craig Nelson, M.D.,
Kevin Delucchi, Ph.D., and
Lon S. Schneider, M.D.

Pages:605–613
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc605

Abstract
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Objective:Second-generation antidepressants are commonly used to treat major depression in late-life. This systematic review and meta-analysis was undertaken to assess the evidence for efficacy of second-generation antidepressants in late-life major ...

October 2010

A Randomized, Controlled Trial of Cognitive-Behavioral Therapy for Augmenting Pharmacotherapy in Obsessive-Compulsive Disorder

Helen Blair Simpson, M.D., Ph.D.,
Edna B. Foa, Ph.D.,
Michael R. Liebowitz, M.D.,
Deborah Roth Ledley, Ph.D.,
Jonathan D. Huppert, Ph.D.,
Shawn Cahill, Ph.D.,
Donna Vermes, M.S., N.P.P.,
Andrew B. Schmidt, L.C.S.W.,
Elizabeth Hembree, Ph.D.,
Martin Franklin, Ph.D.,
Raphael Campeas, M.D.,
Chang-Gyu Hahn, M.D., Ph.D., and
Eva Petkova, Ph.D.

Pages:614–625
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc614

Abstract
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Objective:Although serotonin reuptake inhibitors (SRIs) are approved for the treatment of obsessive-compulsive disorder (OCD), most OCD patients who have received an adequate SRI trial continue to have clinically significant OCD symptoms. The purpose of ...

October 2010

Cognitive-Behavioral Therapy for Medication-Resistant Schizophrenia: A Review

Shanaya Rathod, M.D., MRCPsych,
David Kingdon, M.D.,
Peter Weiden, M.D., and
Douglas Turkington, M.D.

Pages:626–637
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc626

Abstract
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Research meta-analyses have found that cognitive-behavioral therapy (CBT) is beneficial for persistent symptoms of schizophrenia. This review describes and updates the evidence base for this statement. A review of the existing literature (Medline, ...

October 2010

Determinants of Real-World Functional Performance in Schizophrenia Subjects: Correlations With Cognition, Functional Capacity, and Symptoms

Christopher R. Bowie, Ph.D.,
Abraham Reichenberg, Ph.D.,
Thomas L. Patterson, Ph.D.,
Robert K. Heaton, Ph.D., and
Philip D. Harvey, Ph.D.

Pages:638–646
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc638

Abstract
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Objective:Impairments in adaptive life skills are a major source of disability in patients with schizophrenia. The relationship between adaptive life skills in real world settings and performance on neuropsychological tests may be complicated by other ...

October 2010

Prediction of Antidepressant Response to Milnacipran by Norepinephrine Transporter Gene Polymorphisms

Keizo Yoshida, M.D., Ph.D.,
Hitoshi Takahashi, M.D., Ph.D.,
Hisashi Higuchi, M.D., Ph.D.,
Mitsuhiro Kamata, M.D., Ph.D.,
Ken-ichi Ito, M.D., Ph.D.,
Kazuhiro Sato, M.D., Ph.D.,
Shingo Naito, M.D.,
Tetsuo Shimizu, M.D., Ph.D.,
Kunihiko Itoh, Ph.D.,
Kazuyuki Inoue, M.S.C.,
Toshio Suzuki, Ph.D., and
Charles B. Nemeroff, M.D., Ph.D.

Pages:647–653
Published Online:1 October 2010

https://doi.org/10.1176/foc.8.4.foc647

Abstract
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Objective:With a multitude of antidepressants available, predictors of response to different classes of antidepressants are of considerable interest. The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and ...

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