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FOCUS

Volume 21, Issue 3

Novel Mechanisms and Interventions for PTSD

July 2023

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From the Guest Editor

July 2023

New Horizons in the Assessment and Treatment of Posttraumatic Stress Disorder

Negar Fani, Ph.D.

Pages:237–238
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230013

Full text
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Reviews

July 2023

Assessment of Traumatic Stress Symptoms During the Acute Posttrauma Period

Zoe M. F. Brier, M.A.,
Johanna E. Hidalgo, B.A.,
Hannah C. Espeleta, Ph.D.,
Tatiana Davidson, Ph.D.,
Kenneth J. Ruggiero, Ph.D.,
Matthew Price, Ph.D.

Pages:239–246
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230001

Abstract
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Preview Abstract

A substantial majority of adults in the United States will experience a potentially traumatic event (PTE) in their lifetime. A considerable proportion of those individuals will go on to develop posttraumatic stress disorder (PTSD). Distinguishing between ...

July 2023

A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder

Benjamin R. Lewis, M.D., and
Kevin Byrne, M.D.

Pages:247–256
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20220088

Abstract
Full text
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Posttraumatic stress disorder (PTSD) is a common chronic and disabling psychiatric disorder that may develop after exposure to a traumatic life event. There are existing evidence-based psychotherapies and pharmacotherapies for PTSD; however, these ...

July 2023

Ketamine for Treatment of Posttraumatic Stress Disorder: State of the Field

Rachel Fremont, M.D., Ph.D.,
Oneysha Brown, B.A.,
Adriana Feder, M.D.,
James Murrough, M.D., Ph.D.

Pages:257–265
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230006

Abstract
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Posttraumatic stress disorder (PTSD) is a chronic and debilitating condition. Although several psychotherapeutic and pharmacological treatments are recommended for PTSD, many individuals do not respond to treatment or respond only partially, highlighting ...

July 2023

Interoception in Fear Learning and Posttraumatic Stress Disorder

Sonalee A. Joshi, Ph.D.,
Robin L. Aupperle, Ph.D.,
Sahib S. Khalsa, M.D., Ph.D.

Pages:266–277
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230007

Abstract
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Posttraumatic stress disorder (PTSD) is a psychiatric condition characterized by sustained symptoms, including reexperiencing, hyperarousal, avoidance, and mood alterations, following exposure to a traumatic event. Although symptom presentations in PTSD ...

Ask the Expert

July 2023

Treating Motivational and Consummatory Aspects of Anhedonia

Michael T. Treadway, Ph.D.

Pages:278–280
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230008

First Page
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Ethics Commentary

July 2023

Ethical and Legal Aspects of Trauma Evaluation

Jacob M. Appel, M.D., J.D.

Pages:281–285
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.20230005

First Page
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Bibliography

July 2023

Novel Mechanisms and Interventions for PTSD

Pages:286–287
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021010

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Abstracts

July 2023

Novel Mechanisms and Interventions for PTSD

Pages:288–289
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021015

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Influential Publications

July 2023

The Lingering Impact of Resolved PTSD on Subsequent Functioning

Richard A. Bryant,
Alexander C. McFarlane,
Derrick Silove,
Meaghan L. O’Donnell,
David Forbes,
Mark Creamer

Pages:290–295
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021016

Abstract
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This study investigated whether impairment persists after posttraumatic stress disorder (PTSD) has resolved. Traumatically injured patients (N = 1,035) were assessed during hospital admission and at 3 (85%) and 12 months (73%). Quality of life prior to ...

July 2023

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder

Adriana Feder, M.D.,
Sara Costi, M.D.,
Sarah B. Rutter, M.A.,
Abigail B. Collins, B.S.,
Usha Govindarajulu, Ph.D.,
Manish K. Jha, M.D.,
Sarah R. Horn, M.A.,
Marin Kautz, M.A.,
Morgan Corniquel, M.A.,
Katherine A. Collins, Ph.D., M.S.W.,
Laura Bevilacqua, M.D., Ph.D.,
Andrew M. Glasgow, M.D.,
Jess Brallier, M.D.,
Robert H. Pietrzak, Ph.D., M.P.H.,
James W. Murrough, M.D., Ph.D.,
Dennis S. Charney, M.D.

Pages:296–305
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021014

Abstract
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Objective:Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors’ previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine ...

July 2023

Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline

Allison A. Feduccia,
Lisa Jerome,
Berra Yazar-Klosinski,
Amy Emerson,
Michael C. Mithoefer,
Rick Doblin

Pages:306–314
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021013

Abstract
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Unsuccessfully treated posttraumatic stress disorder (PTSD) is a serious and life-threatening disorder. Two medications, paroxetine hydrochloride and sertraline hydrochloride, are approved treatments for PTSD by the Food and Drug Administration (FDA). ...

July 2023

MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study

Pages:315–328
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021011

Abstract
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Supplement

Preview Abstract

Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (...

July 2023

Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy

Lauren Lepow,
Hirofumi Morishita,
Rachel Yehuda

Pages:329–336
Published Online:14 July 2023

https://doi.org/10.1176/appi.focus.23021012

Abstract
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As psychedelic compounds gain traction in psychiatry, there is a need to consider the active mechanism to explain the effect observed in randomized clinical trials. Traditionally, biological psychiatry has asked how compounds affect the causal pathways of ...

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