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FOCUS

Volume 21, Issue 4

Assessment and Management of Bipolar Disorder

October 2023

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From the Guest Editor

October 2023

Updates in the Assessment and Management of Bipolar Disorder

Trisha Suppes, M.D., Ph.D.

Page:343
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230016

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Reviews

October 2023

The CANMAT and ISBD Guidelines for the Treatment of Bipolar Disorder: Summary and a 2023 Update of Evidence

Kamyar Keramatian, M.D., F.R.C.P.C.,
Nellai K. Chithra, M.B.B.S., M.D.,
Lakshmi N. Yatham, M.B.B.S., F.R.C.P.C.

Pages:344–353
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230009

Abstract
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Bipolar disorder is a complex and heterogeneous psychiatric condition that affects more than 2% of the population. The assessment and treatment of bipolar disorder can be a challenge for clinicians, given its clinical complexity and the rapidly changing ...

October 2023

Bipolar II Disorder: Understudied and Underdiagnosed

Holly A. Swartz, M.D., and
Trisha Suppes, M.D., Ph.D.

Pages:354–362
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230015

Abstract
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Despite its inclusion as a distinct entity in APA’s Diagnostic and Statistical Manual of Mental Disorders since 1994, bipolar II disorder remains a surprisingly neglected psychiatric condition. Understudied and underrecognized, bipolar II disorder is ...

October 2023

Cognition in Bipolar Disorder: An Update for Clinicians

Jennifer Nicoloro-SantaBarbara, Ph.D.,
Marzieh Majd, Ph.D., Pharm.D.,
Kamilla Miskowiak, Ph.D.,
Katharine Burns, B.A.,
Benjamin I. Goldstein, M.D., Ph.D.,
Katherine E. Burdick, Ph.D.

Pages:363–369
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230012

Abstract
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Bipolar disorder is associated with cognitive deficits, which persist across mood states and affect functional outcomes. This article provides an overview of recent progress in measuring cognition in bipolar disorder and its implications for both research ...

October 2023

Bipolar Disorder Among Older Adults: Newer Evidence to Guide Clinical Practice

Annemiek Dols, M.D., Ph.D.,
Harmehr Sekhon, Ph.D.,
Soham Rej, M.D.,
Federica Klaus, M.D., Ph.D.,
Katie Bodenstein, B.Sc., M.Sc.,
Martha Sajatovic, M.D.

Pages:370–379
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230010

Abstract
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The term older-age bipolar disorder (OABD) refers to patients with bipolar disorder who are ages 50 and older. Research findings suggest important differences, including the attenuation of manic symptoms with age and the occurrence of multiple somatic ...

October 2023

Suicide Assessment and Prevention in Bipolar Disorder: How Current Evidence Can Inform Clinical Practice

Niloofar Izadi, M.D.,
Rachel H.B. Mitchell, M.D., M.Sc.,
Peter Giacobbe, M.D., M.Sc.,
Sean Nestor, M.D., Ph.D.,
Rosalie Steinberg, M.D., M.Sc.,
Jasmine Amini, H.B.Sc.,
Mark Sinyor, M.D., M.Sc.,
Ayal Schaffer, M.D.

Pages:380–388
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230011

Abstract
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Bipolar disorder is associated with a considerable risk of suicide, and this fact must be incorporated into management of all patients with the condition. This article highlights the importance of a more nuanced understanding of the factors associated ...

Communication Commentary

October 2023

Engaging Through the Elation: Forming an Early Therapeutic Rapport With a Patient With Bipolar Disorder

Dorothy E. Stubbe, M.D.

Pages:389–393
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230017

First Page
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Ethics Commentary

October 2023

Ethical and Legal Aspects of Treating Bipolar Disorder

Jacob M. Appel, M.D., J.D.

Pages:394–398
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.20230014

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Bibliography

October 2023

Assessment and Management of Bipolar Disorder

Pages:399–400
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021017

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Abstracts

October 2023

Assessment and Management of Bipolar Disorder

Page:401
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021019

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Influential Publications

October 2023

Prevention of Suicidal Behavior in Bipolar Disorder

Leonardo Tondo,
Gustavo H. Vázquez,
Ross J. Baldessarini

Pages:402–411
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021025

Abstract
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Background:Excess mortality is a critical hallmark of bipolar disorder (BD) due to co-occurring general medical disorders and especially from suicide. It is timely to review of the status of suicide in BD and to consider the possibility of limiting ...

October 2023

A Risk Calculator to Predict Suicide Attempts Among Individuals With Early-Onset Bipolar Disorder

Tina R. Goldstein,
John Merranko,
Danella Hafeman,
Mary Kay Gill,
Fangzi Liao,
Craig Sewall,
Heather Hower,
Lauren Weinstock,
Shirley Yen,
Benjamin Goldstein,
Martin Keller,
Michael Strober,
Neal Ryan,
Boris Birmaher

Pages:412–419
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021023

Abstract
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Objectives:To build a one-year risk calculator (RC) to predict individualized risk for suicide attempt in early-onset bipolar disorder.Methods:Youth numbering 394 with bipolar disorder who completed ≥2 follow-up assessments (median follow-up length = 13.1 ...

October 2023

Real-World Effectiveness of Repeated Ketamine Infusions for Treatment-Resistant Bipolar Depression

Farhan Fancy,
Nelson B. Rodrigues,
Joshua D. Di Vincenzo,
Edmond H. Chau,
Rickinder Sethi,
Muhammad I. Husain,
Hartej Gill,
Aniqa Tabassum,
Andrea Mckenzie,
Lee Phan,
Roger S. McIntyre,
Joshua D. Rosenblat

Pages:420–429
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021022

Abstract
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Background:Clinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real-world effectiveness of ...

October 2023

Lower Switch Rate in Depressed Patients With Bipolar II Than Bipolar I Disorder Treated Adjunctively With Second-Generation Antidepressants

Lori L. Altshuler, M.D.,
Trisha Suppes, M.D., Ph.D.,
David O. Black, Ph.D.,
Willem A. Nolen, M.D.,
Gabriele Leverich, M.S.W.,
Paul E. Keck, M.D.,
Mark A. Frye, M.D.,
Ralph Kupka, M.D.,
Susan L. McElroy, M.D.,
Heinz Grunze, M.D., Ph.D.,
Christina M.R. Kitchen, Ph.D.,
Robert Post, M.D.

Pages:430–433
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021020

Abstract
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Objectives:The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder.Methods:In a 10-week trial, 184 outpatients with bipolar depression (...

October 2023

Treatment of Bipolar Disorders in Older Adults: A Review

Nemanja Ljubic,
Bianca Ueberberg,
Heinz Grunze,
Hans-Jörg Assion

Pages:434–443
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021024

Abstract
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Background:Old age bipolar disorder has been an orphan of psychiatric research for a long time despite the fact that bipolar disorder (BD)-I and II together may affect 0.5–1.0% of the elderly. It is also unclear whether aetiology, course of illness and ...

October 2023

Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative

Pages:444–452
Published Online:16 October 2023

https://doi.org/10.1176/appi.focus.23021021

Abstract
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Objectives:Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community ...

Self-Assessment and CME

Take the Fall 2023 Focus CME quiz:
Assessment and Management of Bipolar Disorder

Take the 2023 Focus Self-Assessment Examination:
Focus 2023 - Self-Assessment Examination

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