The American Psychiatric Association (APA) has updated its Privacy Policy and Terms of Use, including with new information specifically addressed to individuals in the European Economic Area. As described in the Privacy Policy and Terms of Use, this website utilizes cookies, including for the purpose of offering an optimal online experience and services tailored to your preferences.

Please read the entire Privacy Policy and Terms of Use. By closing this message, browsing this website, continuing the navigation, or otherwise continuing to use the APA's websites, you confirm that you understand and accept the terms of the Privacy Policy and Terms of Use, including the utilization of cookies.

×
BibliographyFull Access

Novel Mechanisms and Interventions for PTSD

This section contains a compilation of recent publications that have shaped the thinking in the field as well as classic works that remain important to the subject reviewed in this issue. This bibliography has been compiled by experts in the field. Articles from the bibliography that are reprinted in this issue are in bold type.

References

Abdallah CG, Averill LA, Akiki TJ, et al.: The neurobiology and pharmacotherapy of posttraumatic stress disorder. Annu Rev Pharmacol Toxicol 2019; 59:171–189CrossrefGoogle Scholar

Abdallah CG, Roache JD, Gueorguieva R, et al.: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology 2022; 47:1574–1581CrossrefGoogle Scholar

Bryant RA: Acute stress disorder as a predictor of posttraumatic stress disorder: a systematic review. J Clin Psychiatry 2011; 72:233–239CrossrefGoogle Scholar

Bryant RA, McFarlane AC, Silove D, et al.: The lingering impact of resolved PTSD on subsequent functioning. Clin Psychol Sci 2016; 4:493–498CrossrefGoogle Scholar

deRoon-Cassini TA, Hunt JC, Geier TJ, et al.: Screening and treating hospitalized trauma survivors for posttraumatic stress disorder and depression. J Trauma Acute Care Surg 2019; 87:440–450CrossrefGoogle Scholar

Feder A, Costi S, Rutter SB, et al.: A randomized controlled trial of repeated ketamine administration for chronic posttraumatic stress disorder. Am J Psychiatry 2021; 178:193–202CrossrefGoogle Scholar

Feduccia AA, Jerome L, Yazar-Klosinski B, et al.: Breakthrough for trauma treatment: safety and efficacy of MDMA-assisted psychotherapy compared to paroxetine and sertraline. Front Psychiatry 2019; 10:650–659CrossrefGoogle Scholar

Forman-Hoffman V, Middleton JC, Feltner C, et al.: Psychological and Pharmacological Treatments for Adults with Posttraumatic Stress Disorder: A Systematic Review Update. Rockville, MD, Agency for Healthcare Research and Quality, 2022Google Scholar

Freudenmann RW, Öxler F, Bernschneider-Reif S: The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction 2006; 101:1241–1245CrossrefGoogle Scholar

Garfinkel SN, Gould van Praag CD, Engels M, et al.: Interoceptive cardiac signals selectively enhance fear memories. J Exp Psychol Gen 2021; 150:1165–1176CrossrefGoogle Scholar

Green AR, Mechan AO, Elliott JM, et al.: The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”). Pharmacol Rev 2003; 55:463–508CrossrefGoogle Scholar

Grob CS, Poland RE, Chang L, et al.: Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observations. Behav Brain Res 1996; 73:103–107CrossrefGoogle Scholar

Jovanovic T, Ressler KJ: How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. Am J Psychiatry 2010; 167:648–662CrossrefGoogle Scholar

Kearney BE, Lanius RA: The brain-body disconnect: a somatic sensory basis for trauma-related disorders. Front Neurosci 2022; 16:1015749CrossrefGoogle Scholar

Khalsa SS, Adolphs R, Cameron OG, et al.: Interoception and mental health: a roadmap. Biol Psychiatry Cogn Neurosci Neuroimaging 2018; 3:501–513CrossrefGoogle Scholar

Kilpatrick DG, Resnick HS, Milanak ME, et al.: National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. J Trauma Stress 2013; 26:537–547CrossrefGoogle Scholar

Krediet E, Bostoen T, Breeksema J, et al.: Reviewing the potential of psychedelics for the treatment of PTSD. Int J Neuropsychopharmacol 2020; 23:385–400CrossrefGoogle Scholar

Kuypers KP, Dolder PC, Ramaekers JG, et al.: Multifaceted empathy of healthy volunteers after single doses of MDMA: a pooled sample of placebo-controlled studies. J Psychopharmacol 2017; 31:589–598CrossrefGoogle Scholar

Lepow L, Morishita H, Yehuda R: Critical period plasticity as a framework for psychedelic-assisted psychotherapy. Front Neurosci 2021; 15:710004CrossrefGoogle Scholar

Maddox SA, Hartmann J, Ross RA, et al.: Deconstructing the gestalt: mechanisms of fear, threat, and trauma memory encoding. Neuron 2019; 102:60–74CrossrefGoogle Scholar

Maren S, Phan KL, Liberzon I: The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 2013; 14:417–428CrossrefGoogle Scholar

Marseille E, Kahn JG, Yazar-Klosinski B, et al.: The cost-effectiveness of MDMA-assisted psychotherapy for the treatment of chronic, treatment-resistant PTSD. PLoS One 2020; 15:e0239997CrossrefGoogle Scholar

Merians AN, Spiller T, Harpaz-Rotem I, et al.: Post-traumatic stress disorder. Med Clin North Am 2023; 107:85–99CrossrefGoogle Scholar

Mitchell JM, Bogenschutz M, Lilienstein A, et al.: MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med 2021; 27:1025–1033CrossrefGoogle Scholar

Mithoefer MC, Feduccia AA, Jerome L, et al.: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology (Berl) 2019; 236:2735–2745CrossrefGoogle Scholar

Mithoefer MC, Wagner MT, Mithoefer AT, et al.: The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 2011; 25:439–452CrossrefGoogle Scholar

Norbury A, Rutter SB, Collins AB, et al.: Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence. Neuropsychopharmacology 2021; 46:2266–2277CrossrefGoogle Scholar

Ot’alora GM, Grigsby J, Poulter B, et al.: 3,4-methylenedioxymethamphetamine-assisted psychotherapy for treatment of chronic posttraumatic stress disorder: a randomized phase 2 controlled trial. J Psychopharmacol 2018; 32:1295–1307CrossrefGoogle Scholar

Price M, van Stolk-Cooke K, Brier ZMF, et al.: mHealth solutions for early interventions after trauma: improvements and considerations for assessment and intervention throughout the acute post-trauma period. MHealth 2018; 4:22CrossrefGoogle Scholar

Schenk S, Newcombe D: Methylenedioxymethamphetamine (MDMA) in psychiatry: pros, cons, and suggestions. J Clin Psychopharmacol 2018; 38:632–638CrossrefGoogle Scholar

Thal SB, Lommen MJ: Current perspective on MDMA-assisted psychotherapy for posttraumatic stress disorder. J Contemp Psychother 2018; 48:99–108CrossrefGoogle Scholar

Wagner MT, Mithoefer MC, Mithoefer AT, et al.: Therapeutic effect of increased openness: investigating mechanism of action in MDMA-assisted psychotherapy. J Psychopharmacol 2017; 31:967–974CrossrefGoogle Scholar