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FOCUS

Volume 6, Issue 2

Schizophrenia

April 2008

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From the Guest Editors

April 2008

From the Guest Editors

John M. Kane, M.D.,
Peter F. Buckley, M.D., and
Stephen R. Marder, M.D.

Page:165
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc165

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CLINICAL SYNTHESIS

April 2008

New-Onset Schizophrenia: Pharmacologic Treatment

John M. Kane, M.D.

Pages:167–171
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc167

Abstract
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The management of new-onset schizophrenia represents an enormous challenge and opportunity. The evaluation and treatment decisions that are implemented at this phase of illness can have an important impact on subsequent course and outcome. It is important ...

April 2008

Schizophrenia Host Vulnerability and Risk of Metabolic Disturbances During Treatment with Antipsychotics

Peter F. Buckley, M.D.,
Adriana Foster, M.D., and
Brian Miller, M.D., M.P.H.

Pages:172–179
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc172

Abstract
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People with schizophrenia die prematurely from comorbid physical diseases, particularly from cardiometabolic disturbances. Although some host vulnerability exists, there is also mounting evidence of a relationship between metabolic disturbances and ...

April 2008

Neurocognition as a Treatment Target in Schizophrenia

Stephen R. Marder, M.D.

Pages:180–183
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc180

Abstract
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Recent attention has focused on the limitations of current antipsychotic medications for improving community functioning in schizophrenia. The strong relationship between neurocognition and functional outcome has led to a focus on developing ...

April 2008

Ask the Expert: Schizophrenia

Jon Streltzer, M.D., and
Wen-Shing Tseng, M.D.

Page:184
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc184

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April 2008

Patient Management Exercise Schizophrenia

Harrison Levine, M.D., M.P.H., and
Ronald C. Albucher, M.D.

Pages:185–196
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc185

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INFLUENTIAL PUBLICATIONS

April 2008

Bibliography Schizophrenia

Pages:197–199
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc197

Abstract
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This section contains a compilation of recent publications that have shaped the thinking in the field as well as classic works that remain important to the subject reviewed in this issue. This bibliography has been compiled by experts in the field and ...

April 2008

Pages:200–204
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc200

First Page
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April 2008

New Paradigms for Treatment Development

Ellen L. Stover,
Linda Brady, and
Stephen R. Marder

Pages:205–211
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc205

Abstract

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(Reprinted with permission from the Schizophrenia Bulletin 2007; 33(5):1093–1099)

April 2008

Adding or Switching Antipsychotic Medications in Treatment-Refractory Schizophrenia

Julie Kreyenbuhl, Pharm.D., Ph.D.,
Steven C. Marcus, Ph.D.,
Joyce C. West, Ph.D., M.P.P.,
Joshua Wilk, Ph.D., and
Mark Olfson, M.D., M.P.H.

Pages:212–220
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc212

Abstract
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Objective:This study compared patients with schizophrenia whose antipsychotic medications were switched to manage treatment-resistant positive psychotic symptoms with those for whom another antipsychotic was added. Psychiatrists' characteristics and ...

April 2008

Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder

David L. Braff,
Robert Freedman,
Nicholas J. Schork, and
Irving I. Gottesman

Pages:221–233
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc221

Abstract

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(Reprinted with permission from the Schizophrenia Bulletin 2007; 3(1):21–32)

April 2008

Sexual Dysfunction in Schizophrenia

Peter Malik

Pages:234–238
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc234

Abstract
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Purpose of review Sexual dysfunctions have been described as being common in schizophrenia patients. The pathophysiology behind their development remains unclear. They can be secondary to the disease itself or an adverse event of antipsychotic medication. ...

April 2008

Mortality and Medical Comorbidity Among Patients With Serious Mental Illness

Brian J. Miller, M.D., M.P.H.,
C. Bayard Paschall, Ph.D., and
Dale P. Svendsen, M.D., M.S.

Pages:239–245
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc239

Abstract
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Objectives:This study examined mortality and medical comorbidity among patients with serious mental illness in Ohio. Methods: Data for 20,018 patients admitted to an Ohio public mental health hospital between 1998 and 2002 were matched against state death ...

April 2008

Medication-Induced Weight Gain and Dyslipidemia in Patients With Schizophrenia

Wayne S. Fenton, M.D., and
Mark R. Chavez, Ph.D.

Pages:246–253
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc246

Abstract
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“Mr. P,” a 40-year-old unmarried man, sought treatment after a move to live closer to his sister. He had attended a first-rate university and worked as a legal researcher before suffering a psychotic episode in 1994 as a first-year law student at age 28. ...

April 2008

Prenatal Infection as a Risk Factor for Schizophrenia

Alan S. Brown

Pages:254–256
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc254

Abstract

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(Reprinted with permission from the Schizophrenia Bulletin 2006; 32(2):200–202)

April 2008

Cognitive Behavior Therapy for Schizophrenia

Douglas Turkington, M.D.,
David Kingdon, M.D., and
Peter J. Weiden, M.D.

Pages:257–266
Published Online:1 April 2008

https://doi.org/10.1176/foc.6.2.foc257

Abstract
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Objective:A growing body of evidence supports the use of cognitive behavior therapy for the treatment of schizophrenia. A course of cognitive behavior therapy, added to the antipsychotic regimen, is now considered to be an appropriate standard of care in ...

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