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FOCUS

Volume 19, Issue 1

Perspectives in Psychopharmacology

January 2021

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From the Guest Editor

January 2021

Navigating the Novel Psychotropics

Boadie W. Dunlop, M.D., MSCR

Pages:1–2
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200044

Full text
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Review

CME

January 2021

Contrasting Typical and Atypical Antipsychotic Drugs

Herbert Y. Meltzer, M.D., and
Erick Gadaleta, D.O.

Pages:3–13
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200051

Abstract
Full text
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CME

Preview Abstract

The beliefs that antipsychotic drugs (APDs) are 1) effective only to treat delusions and hallucinations (positive symptoms), 2) that typical and atypical APDs differ only in ability to cause extrapyramidal side effects, and 3) that their efficacy as ...

Clinical Synthesis

CME

January 2021

Tardive Dyskinesia: Spotlight on Current Approaches to Treatment

Sarah M. Debrey, M.D., and
David R. Goldsmith, M.D.

Pages:14–23
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200038

Abstract
Full text
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CME

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Tardive dyskinesia (TD) is a debilitating, iatrogenic, and potentially severe movement disorder characterized by involuntary, repetitive, purposeless movements that are present throughout the body. The authors present a review of studies of past, current, ...

CME

January 2021

Increasing Psychiatrists’ Role in Addressing the Cardiovascular Health of Patients With Severe Mental Illness

Martha Ward, M.D.

Pages:24–30
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200036

Abstract
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CME

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The early mortality of individuals with serious mental illness has long been documented yet persists despite calls for change. Individuals with serious mental illness have a higher rate of medical morbidity than those in the general population across all ...

CME

January 2021

Novel Formulations of ADHD Medications: Stimulant Selection and Management

Ann C. Childress, M.D.

Pages:31–38
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200032

Abstract
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CME

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Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed psychiatric disorder in children and adolescents in the United States. In 2016, approximately 3.8 million U.S. children ages 2 to 17 years with ADHD were being treated with ...

CME

January 2021

Treatment of Hypoactive Sexual Desire Disorder Among Women: General Considerations and Pharmacological Options

Gabriela S. Pachano Pesantez, M.D., and
Anita H. Clayton, M.D.

Pages:39–45
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200039

Abstract
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CME

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Hypoactive sexual desire disorder (HSDD) is a persistent or recurrent absence of sexual fantasies and desire for sexual activity, causing marked personal distress or interpersonal difficulties. HSDD affects 10% of U.S. women and is associated with ...

CME

January 2021

Innovations in Psychopharmacology Education in U.S. Psychiatric Residency Programs

Jeffrey Rakofsky, M.D.

Pages:46–49
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200037

Abstract
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CME

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Medications available to treat psychiatric illnesses continue to increase, in conjunction with a shifting of outpatient psychiatric practice from psychotherapy toward medication management. To be successful in this climate, a psychiatrist needs to select ...

Ask the Expert

CME

January 2021

Moving on With Monoamine Oxidase Inhibitors

J. Alexander Bodkin, M.D., and
Boadie W. Dunlop, M.D.

Pages:50–52
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200046

First Page
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CME

Ethics Commentary

CME

January 2021

Ethical Issues in Psychopharmacology

Nataly S. Beck, M.D.,
Daniel S. J. Kim, M.D.,
Laura B. Dunn, M.D.

Pages:53–58
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200043

First Page
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CME

21st-Century Psychiatrist

CME

January 2021

COVID-19 and the Doctor-Patient Relationship

David C. Fipps, D.O., and
Elisabet Rainey, M.D.

Pages:59–60
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200033

Abstract
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During a pandemic, physicians can become so inundated with combating the disease that they may forget the individual patient’s experience. In this perspective, the authors describe a case of COVID-19 from the point of view of the grief stages (or ...

CME

January 2021

Integrating Diversity, Equity, and Inclusion Into an Academic Department of Psychiatry and Behavioral Sciences

Nadine J. Kaslow, Ph.D.,
Ann C. Schwartz, M.D.,
Dinah K. Ayna, Ph.D.,
Negar Fani, Ph.D.,
Betsy Gard, Ph.D.,
David R. Goldsmith, M.D.,
Joya Hampton-Anderson, Ph.D.,
Jennifer Holton, M.D.,
Erica D. Marshall-Lee, Ph.D.,
DeJuan White, M.D.,
Jordan E. Cattie, Ph.D.

Pages:61–65
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200024

Abstract
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CME

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This article highlights one department’s efforts to bolster diversity, equity, and inclusion as an exemplar for other academic departments. It offers an approach for building an infrastructure and leadership group and details accomplishments associated ...

Applied Armamentarium

CME

January 2021

Never Say Never: Successful Clozapine Rechallenge After Multiple Episodes of Neutropenia

Michael Shuman, Pharm.D.,
Lori Moss, M.D.,
Adam Dilich, Pharm.D.

Pages:66–70
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.20200029

Abstract
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CME

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Clozapine is a second-generation antipsychotic with a superior efficacy for the management of treatment-resistant schizophrenia but underutilized because of potential side effects. A 59-year-old Caucasian male veteran was transferred from the long-term ...

Bibliography

January 2021

Perspectives in Psychopharmacology

Pages:71–72
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19106

Full text
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Abstracts

January 2021

Perspectives in Psychopharmacology

Pages:73–75
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19105

First Page
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Influential Publication

January 2021

Combinatorial Pharmacogenomic Testing Improves Outcomes for Older Adults With Depression

Brent P. Forester, M.D., M.S.c.,
Sagar V. Parikh, M.D.,
Sara Weisenbach, Ph.D.,
Olusola Ajilore, M.D., Ph.D.,
Ipsit Vahia, M.D.,
Anthony J. Rothschild, M.D.,
Michael E. Thase, M.D.,
Boadie W. Dunlop, M.D.,
Charles DeBattista, D.M.H., M.D.,
Charles R. Conway, M.D.,
Richard C. Shelton, M.D.,
Matthew Macaluso, D.O.,
James Li, Ph.D.,
Paul Traxler, M.S.,
Jennifer Logan, Ph.D.,
Lisa Brown, Ph.D.,
Bryan Dechairo, Ph.D.,
John F. Greden, M.D.

Pages:76–85
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19107

Abstract
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Objective:Evaluate the clinical utility of combinatorial pharmacogenomic testing for informing medication selection among older adults who have experienced antidepressant medication failure for major depressive disorder (MDD).Design:Post hoc analysis of ...

January 2021

Mortality Risk of Antipsychotic Augmentation for Adult Depression

Tobias Gerhard,
T. Scott Stroup,
Christoph U. Correll,
Soko Setoguchi,
Brian L. Strom,
Cecilia Huang,
Zhiqiang Tan,
Stephen Crystal,
Mark Olfson

Pages:86–94
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19101

Abstract
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Importance:Randomized controlled trials have demonstrated increased all-cause mortality in elderly patients with dementia treated with newer antipsychotics. It is unknown whether this risk generalizes to non-elderly adults using newer antipsychotics as ...

January 2021

Psychedelics and Psychedelic-Assisted Psychotherapy

Collin M. Reiff, M.D.,
Elon E. Richman, M.D.,
Charles B. Nemeroff, M.D., Ph.D.,
Linda L. Carpenter, M.D.,
Alik S. Widge, M.D., Ph.D.,
Carolyn I. Rodriguez, M.D., Ph.D.,
Ned H. Kalin, M.D.,
William M. McDonald, M.D., and
the Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research

Pages:95–115
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19104

Abstract
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Objective:The authors provide an evidenced-based summary of the literature on the clinical application of psychedelic drugs in psychiatric disorders.Methods:Searches of PubMed and PsycINFO via Ovid were conducted for articles in English, in peer-reviewed ...

January 2021

The Impact of Pharmacological and Non-Pharmacological Interventions to Improve Physical Health Outcomes in People With Schizophrenia: A Meta-Review of Meta-Analyses of Randomized Controlled Trials

Davy Vancampfort,
Joseph Firth,
Christoph U. Correll,
Marco Solmi,
Dan Siskind,
Marc De Hert,
Rebekah Carney,
Ai Koyanagi,
André F. Carvalho,
Fiona Gaughran,
Brendon Stubbs

Pages:116–128
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19103

Abstract
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We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of 3,709 search ...

January 2021

Safety and Efficacy of Adjunctive Second-Generation Antidepressant Therapy With A Mood Stabiliser or an Atypical Antipsychotic in Acute Bipolar Depression: Randomised Systematic Review and Meta-Analysis of A Placebo-Controlled Trials

Alexander McGirr,
Paul A. Vöhringer,
S. Nassir Ghaemi,
Raymond W. Lam,
Lakshmi N. Yatham

Pages:129–137
Published Online:28 January 2021

https://doi.org/10.1176/appi.focus.19102

Abstract
Full text
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Background:Although mania and hypomania define bipolar disorder, depressive episodes are more common and impairing, with few proven treatments. Adjunctive therapy with second-generation antidepressants is widely used to treat acute bipolar depression, but ...

Take the Winter 2021 Focus CME quiz: Perspectives in Psychopharmacology

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