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FOCUS

Volume 12, Issue 2

Psychopharmacology: Evidence and Treatments

April 2014

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From the Guest Editor

April 2014

From the Guest Editor: New Treatment Advances

Ana D. Stan, M.D., Ph.D., and
Carol A. Tamminga, M.D.

Pages:125–126
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.125

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Clinical Synthesis

April 2014

New Options for the Treatment of Schizophrenia: A Clinical Review of the Three Most Recent Antipsychotic Drugs

Ana D. Stan, M.D., Ph.D., and
Carol A. Tamminga, M.D.

Pages:127–135
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.127

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This clinical review summarizes the pharmacological characteristics, efficacy, and tolerability of asenapine, iloperidone, and lurasidone, the most recently approved antipsychotics in the treatment of schizophrenia.

April 2014

Psychopharmacology of Bipolar II Depression and Bipolar Depression with Mixed Features

Honor Hsin, M.D., Ph.D., and
Trisha Suppes, M.D., Ph.D.

Pages:136–145
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.136

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In this article we focus on the aspects of BD that are difficult to treat clinically and that lie outside most research to date, but nonetheless represent a significant illness burden: BD II depression and BD depression with mixed features.

April 2014

Optimization of Treatment Algorithms for Clinical Depression: Glutamate Antagonists and Transcranial Magnetic Stimulation as Case Examples

Tracy L. Greer, Ph.D., and
Madhukar H. Trivedi, M.D.

Pages:146–151
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.146

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Clinical ContextCurrent treatment approaches for depression are still largely based on trial and error, necessitating adequate guidance for sequential treatment selection and maintenance. Issues surrounding the adequate implementation and integration of ...

April 2014

Advances in Psychopharmacology for Anxiety Disorders

Amir Garakani, M.D.,
James W. Murrough, M.D., and
Dan V. Iosifescu, M.D., M.Sc.

Pages:152–162
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.152

Abstract
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Anxiety disorders are among the most prevalent psychiatric disorders, but compared with mood and psychotic disorders, are understudied in terms of newer pharmacotherapeutic approaches. Here we will review the most recent pharmacological treatment ...

April 2014

Ask the Expert: Psychopharmacology

Alan J. Gelenberg, M.D.

Pages:163–164
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.163

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April 2014

Patient Management Exercise: Psychopharmacology

Ian A. Cook, M.D.

Pages:165–168
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.165

Abstract
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This exercise is designed to test your comprehension of material presented in this issue of FOCUS as well as your ability to evaluate, diagnose, and manage clinical problems. Answer the questions below, to the best of your ability, on the information ...

April 2014

Communication Commentary: Time in a Bottle: The Psychopharmacologist-Patient Relationship in “Split-Treatment” Models of Care

Dorothy E. Stubbe, M.D.

Pages:169–171
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.169

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April 2014

Self-Assessment Activity: Understanding the Evidence for Off-Label Use of Atypical Antipsychotic Medications

Pages:172–177
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.172

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April 2014

Ethics Commentary: Ethics in Psychopharmacology Practice

Honor Hsin, M.D., Ph.D.

Pages:178–183
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.178

First Page
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April 2014

Page:183
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.183

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Influential Publications

April 2014

Bibliography: Psychopharmacology: Evidence and Treatments

Pages:184–186
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.184

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April 2014

Abstracts: Psychopharmacology: Evidence and Treatments

Pages:187–191
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.187

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April 2014

Comparative Efficacy and Tolerability of 15 Antipsychotic Drugs in Schizophrenia: A Multiple-Treatments Meta-Analysis

Stefan Leucht,
Andrea Cipriani,
Loukia Spineli,
Dimitris Mavridis,
Deniz Örey,
Franziska Richter,
Myrto Samara,
Corrado Barbui,
Rolf R Engel,
John R Geddes,
Werner Kissling,
Marko Paul Stapf,
Bettina Lässig,
Georgia Salanti, and
John M Davis

Pages:192–204
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.192

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SummaryBackgroundThe question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence. We aimed to integrate ...

April 2014

Treatment of Bipolar Disorder

John R Geddes, and
David J Miklowitz

Pages:205–216
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.205

Abstract
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We review recent developments in the acute and long-term treatment of bipolar disorder and identify promising future routes to therapeutic innovation. Overall, advances in drug treatment remain quite modest. Antipsychotic drugs are effective in the acute ...

April 2014

Major Depressive Disorder: New Clinical, Neurobiological, and Treatment Perspectives

David J Kupfer,
Ellen Frank, and
Mary L Phillips

Pages:217–228
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.217

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In this Seminar we discuss developments from the past 5 years in the diagnosis, neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and medical comorbidity have been emphasised as important factors in improving the ...

April 2014

Benzodiazepines: Risks and Benefits. A Reconsideration

David S Baldwin,
Katherine Aitchison,
Alan Bateson,
H Valerie Curran,
Simon Davies,
Brian Leonard,
David J Nutt,
David N Stephens, and
Sue Wilson

Pages:229–234
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.229

Abstract
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Over the last decade there have been further developments in our knowledge of the risks and benefits of benzodiazepines, and of the risks and benefits of alternatives to benzodiazepines. Representatives drawn from the Psychopharmacology Special Interest ...

April 2014

International Consensus Study of Antipsychotic Dosing

David M. Gardner, Pharm.D., M.Sc.,
Andrea L. Murphy, Pharm.D.,
Heather O’Donnell, B.Sc. Pharm.,
Franca Centorrino, M.D., and
Ross J. Baldessarini, M.D.

Pages:235–243
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.235

Abstract
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ObjectivePotency equivalents for antipsychotic drugs are required to guide clinical dosing and for designing and interpreting research studies. Available dosing guidelines are limited by the methods and data from which they were generated.MethodWith a two-...

April 2014

Ketamine for Treatment-Resistant Depression: Ready or Not for Clinical Use?

A. John Rush, M.D.

Pages:244–245
Published Online:1 April 2014

https://doi.org/10.1176/appi.focus.12.2.244

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(Reprinted with permission from the American Journal of Psychiatry 2013; 170(10):1079–1081)

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