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FOCUS

Volume 6, Issue 1

Major Depressive Disorder and Suicide

January 2008

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LETTER FROM THE EDITORS

January 2008

Major Depressive Disorder and Suicide

Deborah J. Hales, M.D., and
Mark H. Rapaport, M.D.

Page:1
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc1

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January 2008

Performance in Practice in Maintenance of Certification

Larry R. Faulkner, M.D.

Page:1
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc1a

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CLINICAL SYNTHESIS

January 2008

Recent Findings in the Pathophysiology of Depression

Charles B. Nemeroff, M.D., Ph.D.

Pages:3–14
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc3

First Page
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January 2008

Strategies for the Prevention and Treatment of Suicidal Behavior

Paula Clayton, M.D., and
Tracey Auster, B.A.

Pages:15–21
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc15

Abstract
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This article discusses research-informed strategies for predicting and treating suicidal behavior. One of the most important approaches is to provide training to health professionals in recognizing and treating depression aggressively. An awareness of ...

January 2008

Performance in Practice: Sample Tools for the Care of Patients with Major Depressive Disorder

Laura J. Fochtmann, M.D.,
Farifteh F. Duffy, Ph.D.,
Joyce C. West, Ph.D., M.P.P.,
Robert Kunkle, M.A., and
Robert M. Plovnick, M.D., M.S.

Pages:22–35
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc22

Abstract
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To facilitate continued clinical competence, the American Board of Medical Specialties and the American Board of Psychiatry and Neurology are implementing multi-faceted Maintenance of Certification programs, which include requirements for self-assessments ...

January 2008

Immune System Contributions to the Pathophysiology of Depression

Andrew H. Miller, M.D., and
Charles L. Raison, M.D.

Pages:36–45
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc36

Abstract
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Major depression is a devastating disorder that represents a major public health concern. Of special relevance is the high percentage of patients whose depression does not respond to or who are unable to tolerate conventional antidepressant medications, ...

January 2008

Ask the Expert: Major Depressive Disorder

Glen O. Gabbard, M.D.

Page:46
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc46

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PATIENT MANAGEMENT

January 2008

Patient Management Exercise: Major Depressive Disorder and Suicide

B. Harrison Levine, M.D., M.P.H., and
Ronald C. Albucher, M.D.

Pages:47–57
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc47

First Page
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INFLUENTIAL PUBLICATIONS

January 2008

Bibliography for Major Depressive Disorder and Suicide

Pages:58–62
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc58

Abstract
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This section contains a compilation of recent publications that have shaped the thinking in the field as well as classic works that remain important to the subject reviewed in this issue. This bibliography has been compiled by experts in the field and ...

January 2008

Abstracts For Major Depressive Disorder and Suicide

Pages:63–68
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc63

First Page
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January 2008

Genetic Markers of Suicidal Ideation Emerging During Citalopram Treatment of Major Depression

Gonzalo Laje, M.D.,
Silvia Paddock, Ph.D.,
Husseini Manji, M.D.,
A. John Rush, M.D.,
Alexander F. Wilson, Ph.D.,
Dennis Charney, M.D., and
Francis J. McMahon, M.D.

Pages:69–79
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc69

Abstract
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Objectives:Suicidal ideation is an uncommon symptom than can emerge during antidepressant treatment. The biological basis of treatment-emergent suicidal ideation is unknown. Genetic markers may shed light on the causes of treatment-emergent suicidal ...

January 2008

Suicide Attempts Among Patients Starting Depression Treatment With Medications or Psychotherapy

Gregory E. Simon, M.D., M.P.H., and
James Savarino, Ph.D.

Pages:80–85
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc80

Abstract
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Objectives:This study compared the time patterns of suicide attempts among outpatients starting depression treatment with medication or psychotherapy. Method: Outpatient claims from a prepaid health plan were used to identify new episodes of depression ...

January 2008

Treating Suicidality in Depressive Illness. Part 2: Does Treatment Cure or Cause Suicidality?

Isaac Sakinofsky, M.D., F.R.C.P.C., F.R.C.Psych.

Pages:86–103
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc86

Abstract

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Objectives:To systematically review studies of treatment efficacy for suicidality in mood disorders. To consider the evidence for whether antidepressants may induce suicidality. Method: Systematic review of the literature. Results and Conclusions: There ...

January 2008

Cognitive Therapy Versus Medication in Augmentation and Switch Strategies as Second-Step Treatments: A STAR*D Report

Michael E. Thase, M.D.,
Edward S. Friedman, M.D.,
Melanie M. Biggs, Ph.D.,
Stephen R. Wisniewski, Ph.D.,
Madhukar H. Trivedi, M.D.,
James F. Luther, M.A.,
Maurizio Fava, M.D.,
Andrew A. Nierenberg, M.D.,
Patrick J. McGrath, M.D.,
Diane Warden, Ph.D.,
George Niederehe, Ph.D.,
Steven D. Hollon, Ph.D., and
A. John Rush, M.D.

Pages:104–119
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc104

Abstract
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Objectives:The authors compared the effectiveness of cognitive therapy and pharmacotherapy as second-step strategies for outpatients with major depressive disorder who had received inadequate benefit from an initial trial of citalopram. Cognitive therapy ...

January 2008

Randomized Trial of Weekly, Twice-Monthly, and Monthly Interpersonal Psychotherapy as Maintenance Treatment for Women With Recurrent Depression

Ellen Frank, Ph.D.,
David J. Kupfer, M.D.,
Daniel J. Buysse, M.D.,
Holly A. Swartz, M.D.,
Paul A. Pilkonis, Ph.D.,
Patricia R. Houck, M.S.H.,
Paola Rucci, Ph.D.,
Danielle M. Novick, M.S.,
Victoria J. Grochocinski, Ph.D., and
Deborah M. Stapf, B.S.

Pages:120–127
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc120

Abstract
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Objectives:The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment. Method: A total of 233 ...

January 2008

Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

A. John Rush, M.D.,
Madhukar H. Trivedi, M.D.,
Stephen R. Wisniewski, Ph.D.,
Andrew A. Nierenberg, M.D.,
Jonathan W. Stewart, M.D.,
Diane Warden, Ph.D., M.B.A.,
George Niederehe, Ph.D.,
Michael E. Thase, M.D.,
Philip W. Lavori, Ph.D.,
Barry D. Lebowitz, Ph.D.,
Patrick J. McGrath, M.D.,
Jerrold F. Rosenbaum, M.D.,
Harold A. Sackeim, Ph.D.,
David J. Kupfer, M.D.,
James Luther, M.A., and
Maurizio Fava, M.D.

Pages:128–142
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc128

Abstract
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Objective:This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: A broadly ...

January 2008

Deep Brain Stimulation for Treatment-Resistant Depression

Helen S. Mayberg,
Andres M. Lozano,
Valerie Voon,
Heather E. McNeely,
David Seminowicz,
Clement Hamani,
Jason M. Schwalb, and
Sidney H. Kennedy

Pages:143–154
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc143

Abstract
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Treatment-resistant depression is a severely disabling disorder with no proven treatment options once multiple medications, psychotherapy, and electroconvulsive therapy have failed. Based on our preliminary observation that the subgenual cingulate region (...

January 2008

Efficacy of ECT in Depression: A Meta-Analytic Review

Daniel Pagnin, M.D., M.Sc.,
Valéria de Queiroz, M.D., M.Sc.,
Stefano Pini, M.D., and
Giovanni Battista Cassano, M.D.

Pages:155–162
Published Online:1 January 2008

https://doi.org/10.1176/foc.6.1.foc155

Abstract
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This study analyzed the efficacy of electroconvulsive therapy (ECT) in depression by means a meta-analytic review of randomized controlled trials that compared ECT with simulated ECT or placebo or antidepressant drugs and by a complementary meta-analytic ...

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