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Volume 14, Issue 3

Schizophrenia: Advances in Understanding and Treatment

July 2016

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From the Guest Editor

July 2016

Schizophrenia: Advances in Understanding and Treatment

John Lauriello, M.D.

Page:299
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160015

Full text
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Clinical Synthesis

July 2016

Schizophrenia: An Overview

Tahir Rahman, M.D., and
John Lauriello, M.D.

Pages:300–307
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160006

Abstract
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Few changes were made to the diagnostic criteria for schizophrenia in DSM-5. Schizophrenia is a chronic mental illness with positive symptoms (delusions, hallucinations, disorganized speech and behavior), negative symptoms, and cognitive impairment. ...

July 2016

Schizophrenia Pharmacology: Past, Present, and Future Targets for Intervention

Will J. Cronenwett, M.D.

Pages:308–314
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160009

Abstract
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The first medication for schizophrenia was discovered serendipitously. Years later, it was shown that the medication worked by blocking dopamine, and to this date, all available antipsychotic medications also work by blocking dopamine. They differ, ...

July 2016

Beyond Psychopharmacology: Emerging Psychosocial Interventions for Core Symptoms of Schizophrenia

Peter J. Weiden, M.D.

Pages:315–327
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160014

Abstract
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Psychiatrists who work with patients with severe mental illness often are more focused on diagnosis, medical management, and psychopharmacology than on psychosocial treatments. Furthermore, many psychosocial interventions that show great promise may not ...

July 2016

A Review of Childhood-Onset Schizophrenia

Jusleen Kendhari, M.D.,
Ravi Shankar, M.D.,
Laine Young-Walker, M.D.

Pages:328–332
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160007

Abstract
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Schizophrenia is a neurodevelopmental disorder with a multifactorial etiology. Pediatric schizophrenia consists of early-onset schizophrenia (onset prior to age 18 years) and childhood-onset schizophrenia (onset prior to age 13 years). Adolescence has ...

July 2016

Substance Use Disorders and Schizophrenia

Marc Manseau, M.D., M.P.H., and
Michael Bogenschutz, M.D.

Pages:333–342
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160008

Abstract
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Substance use disorders are prevalent co-occurring problems among people with schizophrenia, with lifetime rates approaching 80% in this population when tobacco use is taken into account. Substance use disorders are associated with significant adverse ...

Ask the Expert

July 2016

Partnering With Families

Peter F. Buckley, M.D

Pages:343–344
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160010

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Patient Management Exercise

July 2016

You Are Touching Your Face

B. Harrison Levine, M.D., M.P.H.

Pages:345–348
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160013

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Ethics Commentary

July 2016

Ethical Issues in the Care of People With Schizophrenia

Douglas L. Noordsy, M.D.

Pages:349–353
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160011

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Safety Commentary

July 2016

Aggression and Prevention of Use of Seclusion and Restraint in Inpatient Psychiatry

Geetha Jayaram, M.D., M.B.A.

Pages:354–357
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160016

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Communication Commentary

July 2016

Addressing the Treatment Schism: Optimizing Team-Based Therapeutic Engagement of the Patient With Schizophrenia

Dorothy E. Stubbe, M.D.

Pages:358–360
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.20160012

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Bibliography

July 2016

Bibliography: Schizophrenia: Advances in Understanding and Treatment

Pages:361–362
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140304

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Abstracts

July 2016

Abstracts: Schizophrenia: Advances in Understanding and Treatment

Pages:363–365
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140303

First Page
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Influential Publications

July 2016

Structure of the Psychotic Disorders Classification in DSM-5

Stephan Heckers,
Deanna M. Barch,
Juan Bustillo,
Wolfgang Gaebel,
Raquel Gur,
Dolores Malaspina,
Michael J. Owen,
Susan Schultz,
Rajiv Tandon,
Ming Tsuang,
Jim Van Os,
William Carpenter

Pages:366–369
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140307

Abstract
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Schizophrenia spectrum disorders attract great interest among clinicians, researchers, and the lay public. While the diagnostic features of schizophrenia have remained unchanged for more than 100 years, the mechanism of illness has remained elusive. There ...

July 2016

Antipsychotic-Induced Weight Gain in First-Episode Psychosis Patients: A Meta-Analysis of Differential Effects of Antipsychotic Medications

Cenk Tek,
Suat Kucukgoncu,
Sinan Guloksuz,
Scott W. Woods,
Vinod H. Srihari, and
Aniyizhai Annamalai

Pages:370–377
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140308

Abstract
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Aim:The first-episode psychosis (FEP) represents a critical period to prevent cardiovascular and metabolic morbidity decades later. Antipsychotic (AP)-induced weight gain is one modifiable factor in this period. The purpose of this study is to conduct a ...

July 2016

The Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) Trial: Rationale for Its Methodology and a Review of the Effectiveness of Switching Antipsychotics

Stefan Leucht,
Inge Winter-van Rossum,
Stephan Heres,
Celso Arango,
W. Wolfgang Fleischhacker,
Birte Glenthøj,
Marion Leboyer,
F. Markus Leweke,
Shôn Lewis,
Phillip McGuire,
Andreas Meyer-Lindenberg,
Dan Rujescu,
Shitij Kapur,
René S. Kahn, and
Iris E. Sommer

Pages:378–386
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140302

Abstract
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Background:Most of the 13 542 trials contained in the Cochrane Schizophrenia Group’s register just tested the general efficacy of pharmacological or psychosocial interventions. Studies on the subsequent treatment steps, which are essential to guide ...

July 2016

Impact of Adverse Childhood Experiences on Psychotic-Like Symptoms and Stress Reactivity in Daily Life in Nonclinical Young Adults

Paula Cristóbal-Narváez,
Tamara Sheinbaum,
Sergi Ballespí,
Mercè Mitjavila,
Inez Myin-Germeys,
Thomas R. Kwapil,
Neus Barrantes-Vidal

Pages:387–395
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140301

Abstract
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Background:There is increasing interest in elucidating the association of different childhood adversities with psychosis-spectrum symptoms as well as the mechanistic processes involved. This study used experience sampling methodology to examine (i) ...

July 2016

Subtyping Schizophrenia by Treatment Response: Antipsychotic Development and the Central Role of Positive Symptoms

Jimmy Lee, MBBS, MMed (Psych), MCI,
Hiroyoshi Takeuchi, MD, PhD,
Gagan Fervaha, BSc,
Gwen Li Sin, MBBS, MMed (Psych),
George Foussias, MD, PhD, FRCPC,
Ofer Agid, MD,
Saeed Farooq, PhD, MCPS (Psych), FCPS (Psych),
Gary Remington, MD, PhD, FRCPC

Pages:396–402
Published Online:13 July 2016

https://doi.org/10.1176/appi.focus.140306

Abstract
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We have recently proposed a model for subtyping schizophrenia based on antipsychotic (AP) treatment response. Evidence suggests that APs, both old and new, are comparable in terms of efficacy; however, one AP, clozapine, is uniquely effective in one ...

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