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Focus

Volume 13, Issue 1

Bipolar Disorders

January 2015

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Clinical Synthesis

January 2015

From the Guest Editor: Special Issue on Bipolar Disorders

Jair C. Soares, M.D., Ph.D.

Page:1
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130122

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January 2015

The Neurobiology of Bipolar Disorder: Neuroimaging and Genetics Update

Katie Mahon, Ph.D.
Manuela Russo, Ph.D.
M. Mercedes Perez-Rodriguez, M.D., Ph.D.
Katherine E. Burdick, Ph.D.

Pages:3–11
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130111

Abstract
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Bipolar disorder is a heterogeneous, complex, multidimensional neuropsychiatric condition characterized by episodes of (hypo)mania and depression. The neurobiology of bipolar disorder is undoubtedly complicated, and much remains to be discovered regarding ...

January 2015

Metabolic Comorbidity and Physical Health Implications for Bipolar Disorder: An Update

Rodrigo B. Mansur, M.D.
Roger S. McIntyre, M.D.

Pages:12–18
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130105

Abstract
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Medical comorbidities are overrepresented in individuals with bipolar disorder, including, but not limited to, cardiovascular conditions, autoimmune diseases, cancer, and metabolic disorders. Overweight/obesity, metabolic syndrome, and type 2 diabetes ...

January 2015

Staging Models in Bipolar Disorder

Juan F. Galvez, M.D.
Ives C. Passos, M.D.
Flavio P. Kapczinski, M.D., Ph.D.
Jair C. Soares, M.D., Ph.D.

Pages:19–24
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130110

Abstract
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Since the initial description of bipolar disorder (BD), longitudinal observations suggested that episodes are more frequent as the disorder progressed. Staging models in BD consider that there is a subset of patients who present a more severe course of ...

January 2015

Management of Bipolar Disorder in Children and Adolescents

Luis R. Patino, M.D., M.Sc.
Kaitlyn M. Bruns, B.A.
Natalie M. Witt, B.A.
Nina R. McCune, B.A.
Melissa P. DelBello, M.D., M.S.

Pages:25–36
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130121

Abstract
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Treatment options for bipolar disorder have been primarily studied in adults. However, there is a growing body of research of these treatments in youths with bipolar disorder. Despite this there is still a huge gap in clinical trials performed on adults ...

January 2015

Psychosocial Approaches to the Treatment of Bipolar Disorder

David J. Miklowitz, Ph.D.
Michael J. Gitlin, M.D.

Pages:37–46
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130106

Abstract
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Even when treated with best-practice pharmacotherapy, many patients with bipolar disorder have slow recoveries from illness episodes, high rates of recurrence, and considerable functional impairment. This article reviews randomized trials of psychotherapy ...

Features

January 2015

Ask the Expert: Seclusion and Restraint

Kim J. Masters, M.D.

Pages:47–49
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130104

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January 2015

Patient Management Exercise: Bipolar Disorder: All the World Was Alive

Ian A. Cook, M.D.

Pages:50–53
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130109

Abstract
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This exercise is designed to test your comprehension of material presented in this issue of FOCUS as well as your ability to evaluate, diagnose, and manage clinical problems. Answer the questions below, to the best of your ability, on the information ...

January 2015

Communication Commentary: Bipolar Disorder: The Roller Coaster Ride: Optimizing the Therapeutic Alliance with Patients with Bipolar Disorder

Dorothy Stubbe, M.D.

Pages:54–56
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130108

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January 2015

Appreciation to Reviewers

Page:56
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130123

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January 2015

Ethics Commentary: Ethical Issues in Bipolar Disorder: Three Case Studies

Laura Weiss Roberts, M.D., M.A.

Pages:57–60
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130107

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Influential Publications

January 2015

Bibliography: Bipolar Disorders

Pages:61–63
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130112

First Page
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January 2015

Abstracts: Bipolar Disorders

Pages:64–67
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130113

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January 2015

The Risk of Switch to Mania in Patients With Bipolar Disorder During Treatment With an Antidepressant Alone and in Combination With a Mood Stabilizer

Alexander Viktorin, M.Sc.
Paul Lichtenstein, Ph.D.
Michael E. Thase, M.D.
Henrik Larsson, Ph.D.
Cecilia Lundholm, M.Sc.
Patrik K.E. Magnusson, Ph.D.
Mikael Landén, M.D., Ph.D.

Pages:68–74
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130117

Abstract
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Objective:This study examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated either with antidepressant monotherapy or with an antidepressant in conjunction with a mood stabilizer.Method:Using Swedish national ...

January 2015

The Bipolar Spectrum: Conceptions and Misconceptions

S Nassir Ghaemi, and
Shannon Dalley

Pages:75–84
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130115

Abstract
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Objective:This review aims to address concerns about the potential overinclusiveness and vagueness of bipolar spectrum concepts, and also, concerns about the overlap between bipolar illness and borderline personality.Method:Narrative review based on ...

January 2015

Collaborative Care for Bipolar Disorder: Part II. Impact on Clinical Outcome, Function, and Costs

Mark S. Bauer, M.D.
Linda McBride, M.S.N.
William O. Williford, Ph.D.
Henry Glick, Ph.D.
Bruce Kinosian, M.D.
Lori Altshuler, M.D.
Thomas Beresford, M.D.
Amy M. Kilbourne, Ph.D., M.P.H.
Martha Sajatovic, M.D.
Coauthors for the Cooperative Studies Program 430 Study Team
George Brown, M.D.
Steven G. Eilers, M.D.
Denise Evans, M.D.
Howard Fenn, M.D.
Richard Hauger, M.D.
Gail F. Kirk, M.S.
Aimee Mayeda, M.D.
Janet Tekell, M.D.
Hagop S. Akiskal, M.D.
Joseph F. Collins, Sc.D.
Kousick Biswas, Ph.D.
Pamela Staves, M.S., N.P.
Philip Lavori, Ph.D.

Pages:85–93
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130114

Abstract
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Objective:The study addressed whether a collaborative model for chronic care, described in part I (this issue), improves outcome for bipolar disorder.Methods:The intervention was designed to improve outcome by enhancing patient self-management skills with ...

January 2015

Lithium Treatment Moderate-Dose Use Study (LiTMUS) for Bipolar Disorder: A Randomized Comparative Effectiveness Trial of Optimized Personalized Treatment With and Without Lithium

Andrew A. Nierenberg, M.D.
Edward S. Friedman, M.D.
Charles L. Bowden, M.D.
Louisa G. Sylvia, Ph.D.
Michael E. Thase, M.D.
Terence Ketter, M.D.
Michael J. Ostacher, M.D., M.P.H.
Andrew C. Leon, Ph.D.
Noreen Reilly-Harrington, Ph.D.
Dan V. Iosifescu, M.D.
Michael Pencina, Ph.D.
Joanne B. Severe, M.S.
Joseph R. Calabrese, M.D.

Pages:94–101
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130116

Abstract
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Objective:Lithium salts, once the mainstay of therapy for bipolar disorder, have tolerability issues at a higher dosage that often limit adherence. The authors investigated the comparative effectiveness of more tolerable dosages of lithium as part of ...

January 2015

Overview of Antidepressant Treatment of Bipolar Depression

Gustavo H. Vázquez
Leonardo Tondo
Juan Undurraga
Ross J. Baldessarini

Pages:102–112
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130119

Abstract
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Bipolar depression remains a major unresolved challenge for psychiatric therapeutics. It is associated with significant disability and mortality and represents the major proportion of the approximately half of follow-up time spent in morbid states despite ...

January 2015

Early Intervention for Symptomatic Youth at Risk for Bipolar Disorder: A Randomized Trial of Family-Focused Therapy

David J. Miklowitz, Ph.D.
Christopher D. Schneck, M.D.
Manpreet K. Singh, M.D.
Dawn O. Taylor, Ph.D.
Elizabeth L. George, Ph.D.
Victoria E. Cosgrove, Ph.D.
Meghan E. Howe, M.A.
L. Miriam Dickinson, Ph.D.
Judy Garber, Ph.D.
Kiki D. Chang, M.D.

Pages:113–121
Published Online:23 February 2015

https://doi.org/10.1176/appi.focus.130118

Abstract
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Objective:Depression and brief periods of (hypo)mania are linked to an increased risk of progression to bipolar I or II disorder (BD) in children of bipolar parents. This randomized trial examined the effects of a 4-month family-focused therapy (FFT) ...

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