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FOCUS

Volume 17, Issue 1

Neuroscience-Informed Treatments

January 2019

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From the Guest Editor

January 2019

Neuroscience-Informed Therapies in Psychiatry

Mayada Akil, M.D.

Page:1
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180034

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Reviews

CME

January 2019

Bringing Neuroscience to the Bedside

Joseph J. Cooper, M.D.,
Alexander S. Korb, Ph.D.,
Mayada Akil, M.D.

Pages:2–7
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180033

Abstract
Full text
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CME

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Clinical psychiatry has not historically expected practitioners to learn the basic science of psychiatric illness. Despite wide recognition that all effective psychiatric treatments have neurophysiological mechanisms, the field has struggled to integrate ...

CME

January 2019

Ketamine for Treatment-Resistant Mood Disorders

Lawrence T. Park, M.D.,
Tolulope B. Falodun, B.S.,
Carlos A. Zarate, M.D.

Pages:8–12
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180030

Abstract
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- CME

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Ketamine has been shown to provide relief for typical and atypical depressive symptoms, anxiety in the context of depression, and acute suicidal ideation and behaviors. Evidence also suggests that repeated doses of intranasal ketamine may be effective ...

CME

January 2019

Therapeutic Uses of Seizures in Neuropsychiatry

M. Justin Coffey, M.D., and
Joseph J. Cooper, M.D.

Pages:13–17
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180023

Abstract
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CME

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The contemporary use of ECT for treating certain mental and neurologic disorders is discussed. Two experimental forms of seizure therapy that are related to ECT may hold promise for the future: focal electrically administered seizure therapy (FEAST) and ...

CME

January 2019

A Critical Review and Synthesis of Clinical and Neurocognitive Effects of Noninvasive Neuromodulation Antidepressant Therapies

Shawn M. McClintock, Ph.D., MSCS,
Elisa Kallioniemi, Ph.D.,
Donel M. Martin, Ph.D.,
Joseph U. Kim, Ph.D.,
Sara L. Weisenbach, Ph.D.,
Christopher C. Abbott, M.D., M.S.

Pages:18–29
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180031

Abstract
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This review synthesizes information about application of four noninvasive neuromodulation therapies (e.g., electroconvulsive therapy, magnetic seizure therapy) in treating major depressive disorder. The focus is on antidepressant effects, neurocognitive ...

Ask the Expert

January 2019

Neuroscience and the Future of Psychiatry

Michael J. Travis, M.D.

Pages:30–31
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180032

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Communication Commentary

January 2019

Media Talks: Communicating the Neuroscience Underpinnings of Popular Media Stories

Dorothy E. Stubbe, M.D., and
Mayada Akil, M.D.

Pages:32–34
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180035

First Page
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Ethics Commentary

January 2019

How Neuroscience Is Informing Treatments: Ethical Issues

Kristina Thurin, M.D.,
Zehra N. Aftab, M.D.,
Joseph J. Cooper, M.D.

Pages:35–40
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180028

First Page
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Patient Management Exercise

January 2019

Neuroscience in Clinical Care

Ian A. Cook, M.D.

Pages:41–43
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180036

First Page
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21st-Century Psychiatrist

CME

January 2019

Transcranial Direct Current Stimulation in Psychiatry: What Psychiatrists Need to Know

Amin Zandvakili, M.D., Ph.D.,
Yosef Alfred Berlow, M.D., Ph.D.,
Linda Leigh Carpenter, M.D.,
Noah Stephen Philip, M.D.

Pages:44–49
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.20180029

Abstract
Full text
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CME

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Transcranial direct current stimulation is emerging as a potential treatment for a host of neuropsychiatric disorders, yet study results are mixed. This review covers tDCS essentials for psychiatric clinicians and trainees, including guidelines on tDCS ...

Bibliography

January 2019

Neuroscience-Informed Treatments

Pages:50–51
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17101

Full text
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Abstracts

January 2019

Neuroscience-Informed Treatments

Pages:52–54
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17107

First Page
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Influential Publications

January 2019

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study

Carla M. Canuso, M.D.,
Jaskaran B. Singh, M.D.,
Maggie Fedgchin, Pharm.D.,
Larry Alphs, M.D., Ph.D.,
Rosanne Lane, M.A.S.,
Pilar Lim, Ph.D.,
Christine Pinter, M.S.,
David Hough, M.D.,
Gerard Sanacora, M.D., Ph.D.,
Husseini Manji, M.D.,
Wayne C. Drevets, M.D.

Pages:55–65
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17105

Abstract
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Supplement

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Objective:The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major depression, including suicidality, among individuals at imminent suicide risk.Method:In a double-blind,...

January 2019

Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap

Michael J. Gandal,
Jillian R. Haney,
Neelroop N. Parikshak,
Virpi Leppa,
Gokul Ramaswami,
Chris Hartl,
Andrew J. Schork,
Vivek Appadurai,
Alfonso Buil,
Thomas M. Werge,
Chunyu Liu,
Kevin P. White,
CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group, Steve Horvath,
Daniel H. Geschwind

Pages:66–72
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17103

Abstract
Full text
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The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a ...

January 2019

From Molecules to Mind: Mechanisms of Action of Electroconvulsive Therapy

K. M. Ryan,
D. M. McLoughlin

Pages:73–75
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17104

First Page
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January 2019

Electroconvulsive Therapy Augmentation in Clozapine-Resistant Schizophrenia: A Prospective, Randomized Study

Georgios Petrides, M.D.,
Chitra Malur, M.D.,
Raphael J. Braga, M.D.,
Samuel H. Bailine, M.D.,
Nina R. Schooler, Ph.D.,
Anil K. Malhotra, M.D.,
John M. Kane, M.D.,
Sohag Sanghani, M.D.,
Terry E. Goldberg, Ph.D.,
Majnu John, Ph.D.,
Alan Mendelowitz, M.D.

Pages:76–82
Published Online:10 January 2019

https://doi.org/10.1176/appi.focus.17106

Abstract
Full text
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Objective:Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine ...

Take the Winter 2019 Focus CME quiz: Neuroscience-Informed Therapies in Psychiatry

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