Antipsychotics |
Alcohol | Intensifies CNS depression |
Amphetamines | Antagonizes efficacy |
Antacids | Decreases neuroleptic absorption |
Anticholinergics | Additive anticholinergic effects |
Antihypertensivesa | Hypotension |
Barbiturates | Decreases neuroleptic levels |
Epinephrinea | Hypotension |
Levodopa | Antagonizes levodopa efficacy |
Lithium | Increases neurotoxicity |
MAOIsa | Hypotension |
TCAs | Increases TCA plasma levels |
BZs |
Alcohol (and other CNS depressants) | Intensifies CNS depression |
Alcohol (acute) | Increases BZ levels |
Alcohol (chronic) | Decreases BZ levels |
Antacids | Decreases BZ levels |
Cimetidineb | Increases BZ levels |
Disulfiramb | Increases BZ levels |
SSRIs | Increases BZ levels |
Isoniazidb | Increases BZ levels |
Oral contraceptivesb | Increases BZ levels |
Rifampinb | Decreases BZ levels |
Tobacco/nicotineb | Decreases BZ levels |
Carbamazepine (induces CYP450 3A3/3A4) |
Alprazolam | Decreases alprazolam levels |
Cimetidine | Increases carbamazepine levels |
Clonazepam | Decreases clonazepam levels |
Diltiazem, verapamil | Increases carbamazepine levels |
Erythromycin | Increases carbamazepine levels |
Isoniazid | Increases carbamazepine levels |
Phenobarbital | Decreases carbamazepine levels |
Phenytoin | Decreases carbamazepine levels |
Primidone | Decreases carbamazepine levels |
Propoxyphene | Increases carbamazepine levels |
SSRIs | Increases carbamazepine levels |
Valproate | Decreases valproate levels |
Lithium |
Acetazolamide | Decreases lithium levels |
Antipsychotics | Increases neurotoxicity |
Beta-blockers | Decreases tremor |
Carbamazepine | Increases lithium effects |
Captopril, enalapril | Increases lithium levels |
Cyclosporine | Markedly increases lithium levels |
Diltiazem, verapamil | Increases lithium toxicity |
Methyldopa | Increases lithium toxicity |
Potassium iodide | Enhances hypothyroid effects |
Tetracycline | Increases lithium levels |
Thiazide diuretics | Increases lithium levels |
SSRIs |
BZsb | Increases BZ levels |
Carbamazepine | Increases carbamazepine levels |
Antipsychotics | Increases neuroleptic levels |
TCAs | Increases TCA levels |
MAOIs |
Alcohol | Additive CNS depression |
Clomipramine | Serotonin syndrome |
SSRIs | Serotonin syndrome |
Meperidine | Serotonin syndrome |
Phenothiazine | Hypotension |
Succinylcholine | Prolongs muscle relaxation |
Tyramine | Potential hypertensive crisis |
Sympathomimetic drugs (amphetamine, cocaine, dopamine, ephedrine, epinephrine, metaraminol, norepinephrine, phenylpropanolamine, phenylephrine) | Potential hypertensive crisis |
TCAs |
Alcohol | Additive CNS depression |
Anticholinergics | Additive anticholinergic effects |
Antihypertensives (guanethidine, clonidine, debrisoquin) | Increases hypertension |
Antipsychotics | Increases TCA plasma levels |
BZs | Additive CNS depression |
Class I antiarrhythmics (disopyramide, lidocaine, quinidine, procainamide) | Prolongs cardiac conduction |
Liothyronine | Enhances antidepressant action |