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CLINICAL SYNTHESISFull Access

Quick Reference For Major Depressive Disorder

Published Online:https://doi.org/10.1176/foc.3.1.13

The tables in this section are reprinted with permission from Dubovsky SL, Dubovsky AN: Concise Guide to Mood Disorders, Washington, DC, American Psychiatric Press, 2002.

Table 1. Characteristics of Effective Psychotherapy for Depression
Time-limited treatment
Explicit rationale for treatment, shared by patient and therapist
Active and directive therapist
Focus on current problems
Emphasis on changing current behavior
Self-monitoring of progress
Involvement of significant others
Expression of cautious optimism
Problems divided into manageable units with short-term goals
Homework assignments
Table 1. Characteristics of Effective Psychotherapy for Depression
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Table 2. Questions for Evaluating Inadequate Antidepressant Response
Are the dose and duration of treatment adequate?
Is the patient taking the medication?
Is a medical illness contributing to treatment resistance?
Is the patient taking a medication or substance that is interfering with the antidepressant?
Is the patient truly depressed?
Are psychotic symptoms present?
Is the depression bipolar?
Are psychosocial issues being ignored?
Has the patient’s family been involved in treatment?
Table 2. Questions for Evaluating Inadequate Antidepressant Response
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Table 3. Agents Used to Augment Antidepressant Therapy in Unipolar Depression
Lithium
Stimulants
Carbamazepine
Buspirone
Triiodothyronine (T3)
Gabapentin
Atypical antipsychotic drugs
SSRI–tricyclic antidepressant combination
Mirtazapine-venlafaxine combination
MAOI–tricyclic antidepressant combination

SSRI=selective serotonin reuptake inhibitor; MAOI=monoamine oxidase inhibitor

Table 3. Agents Used to Augment Antidepressant Therapy in Unipolar Depression
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