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Clinical Advances in Pharmacological and Integrated Treatment Approaches for Alcohol and Drug Use Disorders

Correspondence: Address Correspondence to: Dr. Helen Dermatis, New York University Medical Center, Department of Psychiatry-Division of Alcoholism and Drug Abuse, NBV20N28, 550 First Avenue, New York, NY 10016.

In this review, we highlight recent developments in the pharmacological treatment of alcohol and other substance use disorders and in programs designed for those with dual diagnosis disorders. The depot formulation of naltrexone, which recently received U.S. Food and Drug Administration approval, presents a more effective alternative to oral administration for alcohol dependence. Inconsistent support for the efficacy of acamprosate, however, underscores the need for more research concerning its optimal use. Recent testing of a depot naltrexone preparation for opioid-dependent patients shows promise for its clinical use. Buprenorphine represents a viable treatment option for opioid-dependent patients when combined with psychosocial modalities such as network therapy or contingency management. There has been an increase in the number of integrated programs for patients with a dual diagnosis, incorporating evidence-based psychosocial treatments combined with mutual self-help approaches, including 12-step-based and more global peer-led approaches.

CME Disclosure

Helen Dermatis, Ph.D., and Marc Galanter, M.D., Division of Alcoholism and Drug Abuse, New York University Medical Center, Department of Psychiatry, New York.

No relevant financial relationships to disclose.

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				Reference List for FOCUS Self-Assessment Examination PsychiatryOnline CME, October 10, 2007; 2007(3): 2 - 2. [Full Text]

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