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Recent Studies of the Biology and Treatment of Depression

From the Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, California.

Correspondence: Send reprint requests to Dr. Schatzberg, Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, 401 Quarry Road, Stanford, CA 94305-5717; e-mail, afschatz{at}stanford.edu.

Major depression is one of the most common psychiatric disorders, with lifetime prevalence rates of over 15%. Recent research provides new insights on which brain regions are affected in the disorder, underlying biological mechanisms, and possible novel treatments. This review discusses a number of recent research advances in epidemiology, genetics, imaging, treatment, and pharmacogenetics. It also outlines issues or questions that still need to be addressed, and it begins to outline a framework for understanding why and how depression may occur.

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