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CLINICAL SYNTHESIS   |    
Quick Reference Psychosomatic MedicineMed-Psych Drug-Drug Interactions Update An Overview of Psychotropic Drug-Drug Interactions
FOCUS 2009;7:347-364.

Abstract

Source: Sandson NB, Armstrong SC, Cozza KL: Med-Psych Drug-Drug Interactions Update An Overview of Psychotropic Drug-Drug Interactions. Psychosomatics 2005;46:464—494. Reprinted with permission. Please refer to the full article for specific citations of each interaction. 

The psychotropic drug-drug interactions most likely to be relevant to psychiatrists' practices are examined. The metabolism and the enzymatic and P-glycoprotein inhibition/induction profiles of all antidepressants, antipsychotics, and mood stabilizers are described; all clinically meaningful drug-drug interactions between agents in these psychotropic classes, as well as with frequently encountered nonpsychotropic agents, are detailed; and information on the pharmacokinetic/pharmacodynamic results, mechanisms, and clinical consequences of these interactions is presented. Although the range of drug-drug interactions involving psychotropic agents is large, it is a finite and manageable subset of the much larger domain of all possible drug-drug interactions. Sophisticated computer programs will ultimately provide the best means of avoiding drug-drug interactions. Until these programs are developed, the best defense against drug-drug interactions is awareness and focused attention to this issue.

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Figures in this Article

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Appendix 1. Significant Drug-Drug Interactions Involving Antidepressants

 
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Appendix 2. Significant Drug-Drug Interactions Involving Antipsychotics

 
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Appendix 3. Significant Drug-Drug Interactions Involving Mood Stabilizers

 
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Appendix 4. Significant Drug-Drug Interactions Involving Other Psychotropic Agents and Nonpsychotropic Agents

 
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Appendix 4.

Significant Drug-Drug Interactions Involving Other Psychotropic Agents and Nonpsychotropic Agents

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References

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