Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Treating Suicidality in Depressive Illness. Part 2: Does Treatment Cure or Cause Suicidality?
Isaac Sakinofsky, M.D., F.R.C.P.C., F.R.C.Psych.
FOCUS 2008;6:86-103.
text A A A
PDF of the full text article.


Objectives:  To systematically review studies of treatment efficacy for suicidality in mood disorders. To consider the evidence for whether antidepressants may induce suicidality. Method:  Systematic review of the literature. Results and Conclusions:  There is fairly good evidence that lithium reduces completed suicide and attempt rates in people with bipolar disorder and recurrent unipolar depression. Antidepressants and psychological treatments may reduce suicidal ideation in depressed patients. Antidepressant trials do not, however, a priori target suicidality as an outcome, and inferences made are post hoc. For practical reasons, no adequate trials to date have tested the efficacy of treatment aimed at reducing completed suicide in people with depressive disorders. Antidepressants have been implicated in suicide in one metaanalysis (the elderly) and in one case-control study (youth), signalling the need for caution. However, most metaanalyses have found no significant excess of completed suicide among antidepressant users, compared with placebo groups, in adults and juveniles, but excess nonfatal suicidality is found more often in children and adolescents who take antidepressants (except fluoxetine). The controversy is ongoing.
(Reprinted with permission from the Canadian Journal of Psychiatry, 2007; 52 (6 Suppl 1): 85S—191S; full text of the article available online at http://publications.cpa-apc.org/media.php?mid=425) 

Abstract Teaser
Figures in this Article




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Related Content
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 55.  >
Dulcan's Textbook of Child and Adolescent Psychiatry > Chapter 8.  >
The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition > Chapter 17.  >
DSM-5™ Clinical Cases > Chapter 3.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 1.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines
PubMed Articles
Psychosocial impact of acne vulgaris: evaluating the evidence. Skin Therapy Lett 2004 Aug-Sep;9(7):1-3, 9.