For most people, eating, sleep, and sex are among the most enjoyable activities of life. However, for many, some of these functions present problems, taking away from the overall quality of life. For some, one or more of these activities may become a source of unrelenting torment and despair. This issue of FOCUS brings together some of the best current thinking on an array of disorders affecting eating, sleep, and sex that are likely to be of considerable importance to the practicing psychiatrist. To start with, I assembled the same cast that constitutes the work group responsible for drafting APA’s forthcoming third revision of the Practice Guideline for the Treatment of Patients With Eating Disorders as well as the recent Guideline Watch updating the second edition. They assisted me in preparing a clinical synthesis article that summarizes the state of the art in the treatment of anorexia nervosa, bulimia nervosa, binge-eating disorder, and related problems. This presentation anticipates some of the new thinking that will appear in the next revision of the guideline.