In this issue we attempt to provide an overview of this devastating illness. In the clinical synthesis article, we offer a framework for evaluating the first presentation of a patient with psychosis, which includes an approach to interviewing the patient and family members, consideration of the various possible causes of psychosis (with schizophrenia as the prototypical cause), and an emphasis on the immediate need to ensure safety and stability for the patient. In the review article, Jibson and colleagues present a comprehensive review of schizophrenia, including its presentation, underlying biological theories, and state-of-the-art psychosocial and pharmacological treatment. We hope that both articles provide experienced clinicians a worthwhile review and clinicians in training some helpful new information. Finally, more than a dozen influential articles on schizophrenia are reprinted in this issue, covering all facets of the disorder and its treatment.