Healing is the heart of medicine and, by definition, is the central commitment of the therapeutic relationship. In psychiatry, the therapeutic relationship can become deeper and richer in its meaning and influence. The special quality of the therapeutic relationship in psychiatry derives in part from the nature of mental illnesses that carry with them great anguish. The personal suffering associated with mental disorders, related conditions, and difficult life events that bring a patient into the care of a psychiatrist can be immense, cause a profound sense of vulnerability, and may be poorly understood by others—even among those closest to the patient. The therapeutic relationship in psychiatry, particularly but not exclusively in the context of psychotherapy, is also distinct in the House of Medicine because the psychiatrist uses not only special expertise but also the sequence of interactions between psychiatrist and patient—truly the dynamics that exist in the relationship itself—in the service of bringing about greater health in the patient. For these reasons, healing in psychiatry arises through trust in the psychiatrist and the aim of the therapeutic relationship is dedicated to the patient’s well-being.