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Ketamine for Treatment-Resistant Depression: Ready or Not for Clinical Use?
A. John Rush, M.D.
FOCUS 2014;12:244-245. doi:10.1176/appi.focus.12.2.244

(Reprinted with permission from the American Journal of Psychiatry 2013; 170(10):1079–1081) 

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Rush  AJ;  Trivedi  MH;  Wisniewski  SR;  Nierenberg  AA;  Stewart  JW;  Warden  D;  Niederehe  G;  Thase  ME;  Lavori  PW;  Lebowitz  BD;  McGrath  PJ;  Rosenbaum  JF;  Sackeim  HA;  Kupfer  DJ;  Luther  J;  Fava  M:  Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.  Am J Psychiatry 2006; 163:1905–1917
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Murrough  JW;  Iosifescu  DV;  Chang  LC;  Al Jurdi  RK;  Green  CM;  Perez  AM;  Iqbal  S;  Pillemer  S;  Foulkes  A;  Shah  A;  Charney  DS;  Mathew  SJ:  Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.  Am J Psychiatry 2013; 170:1134–1142
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Laje  G;  Lally  N;  Mathews  D;  Brutsche  N;  Chemerinski  A;  Akula  N;  Kelmendi  B;  Simen  A;  McMahon  FJ;  Sanacora  G;  Zarate  C  Jr:  Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients.  Biol Psychiatry 2012; 72:e27–e28
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Wisniewski  SR;  Rush  AJ;  Nierenberg  AA;  Gaynes  BN;  Warden  D;  Luther  JF;  McGrath  PJ;  Lavori  PW;  Thase  ME;  Fava  M;  Trivedi  MH:  Can phase III trial results of antidepressant medications be generalized to clinical practice? a STAR*D report.  Am J Psychiatry 2009; 166:599–607
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Kuk  AY;  Li  J;  Rush  AJ:  Recursive subsetting to identify patients in the STAR*D: a method to enhance the accuracy of early prediction of treatment outcome and to inform personalized care.  J Clin Psychiatry 2010; 71:1502–1508
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Fiore  LD;  Brophy  M;  Ferguson  RE;  D’Avolio  L;  Hermos  JA;  Lew  RA;  Doros  G;  Conrad  CH;  O’Neil  JA  Jr;  Sabin  TP;  Kaufman  J;  Swartz  SL;  Lawler  E;  Liang  MH;  Gaziano  JM;  Lavori  PW:  A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen.  Clin Trials 2011; 8:183–195
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