This issue provides a selected overview of the vital contributions psychosomatic medicine continues to make to U.S. health care delivery. Psychiatrists provide consultations to medically ill patients in the medical inpatient and ambulatory environments, thereby contributing to the comprehensive care of patients with medical and psychiatric comorbidity. The development, implementation, and testing of advanced models of collaborative care of medical patients with psychiatric comorbidities is a critically important advance. Psychosomatic medicine continues to make major contributions to the comprehensive, patient-centered, personalized care of patients with chronic medical disease, cancer, and those undergoing transplantation. Optimal psychopharmacologic care of patients with significant medical illness and comorbid psychiatric disorders requires high-level expertise and judgment. Psychiatrists also continue to make important contributions to neuropsychiatry, including the assessment and management of cognitive impairment.