Other addictive substances reflect their two-faced nature: they are used for their positive effects and despised for the harm they cause. It is easy to understand why we are ambivalent about drugs and about those who misuse, abuse, and become dependent on them. Those who abuse alcohol, for example, may be maligned because they drink excessively, whereas most people limit consumption within appropriate bounds. There is intense research into the science of addiction that promises to explain the varied responses to alcohol and other drugs. Such research is likely to be based on a better understanding of neurotransmitters and the cascade of actions that substances cause, as well as matching psychosocial constructs with the development of addiction. The field awaits advancements in genetics to help in our work.