Does depression affect the baby? Yes it does. Depressed pregnant women are less compliant with obstetrical care, they use more hypnotics, opiates, tobacco, alcohol, and illicit substances, and their children have higher rates of preterm birth, low birth weight, neonatal intensive care unit admission, and poor developmental outcomes [for a review, see Henry et al. (2)]. However, the level of severity of depression necessary to increase risks for these poor outcomes remains unclear. In the absence of concrete data, it is commonly assumed that moderate to severe episodes of depression convey risk to an unborn child. Do not overlook the fact that maternal depression can also affect older siblings.