The original articles in this issue provide state-of-the-art updates on the epidemiology and management of reproductive mood disorders. Gail Erlick Robinson has contributed an overview of psychopharmacology in pregnancy and postpartum. Rita Suri and Lori Altshuler discuss advances in the recognition and treatment of postpartum depression. Luciano Minuzzi, Benicio Frey, and Claudio Soares review current management strategies for depression during the menopausal transition. The FOCUS regular features, Patient Management exercise by Ian Cook and the Ask the Expert column by Karen Padron and Jeffrey Newport, provide a clinical situation and discussion. Finally, Mytilee Vemuri and Laura Weiss Roberts examine ethical considerations in treating women with mental illness during pregnancy.